Antiarrhythmic Pharmacology · Foundation Module 2 of 3

Same uptake. Only τ differs.

All three Class I subclasses are modeled here with identical binding avidity — the only variable changed is how fast the drug lets go. Watch the blocked fraction accumulate beat to beat, then raise the heart rate.

75 bpm

Nav1.5 state cycle

Blocked channels across successive beats

τ recovery
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Diastolic interval
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Steady-state block
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Conduction / QRS
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